Description
Discovery® C8 HPLC Column, 5 µm – Supelco by Merck
The Discovery® C8 HPLC column from Supelco by Merck is a reversed-phase column designed for analytes requiring a less retentive stationary phase than C18. The shorter octyl chain provides moderate hydrophobic retention, making this column particularly valuable for highly non-polar compounds that would be over-retained on C18, as well as for methods requiring faster elution of hydrophobic analytes without sacrificing resolution.
The column is built on high-purity, spherical silica with a fully porous particle platform, providing efficient mass transfer and good column efficiency. With 7.5% carbon loading, a surface area of 200 m²/g, and a surface coverage of 3.4 µmol/m², the Discovery® C8 delivers consistent selectivity and peak shape across a variety of reversed-phase mobile phase systems. The endcapped design minimises residual silanol interactions for improved peak symmetry with basic analytes.
Operating across a pH range of 2–8 with a maximum temperature of 70°C and maximum pressure of 400 bar, these columns are compatible with standard HPLC and LC/MS instrumentation. Metal impurities below 10 ppm support analysis of metal-sensitive compounds, and USP L7 certification enables use in pharmacopoeial analytical methods.
Specifications
| Parameter | Specification |
|---|---|
| Phase | C8 (Octyl) |
| Particle Size | 5 µm |
| Particle Type | Fully porous, spherical |
| Matrix | High-purity silica gel |
| Carbon Loading | 7.5% |
| Surface Area | 200 m²/g |
| Surface Coverage | 3.4 µmol/m² |
| Pore Size | 180 Å |
| Endcapped | Yes |
| Operating pH Range | 2–8 |
| Max. Temperature | ≤70 °C |
| Max. Pressure | 400 bar (5801 psi) |
| Metal Impurities | <10 ppm |
| Column Material | Stainless steel |
| USP Classification | L7 |
| Separation Technique | Reversed phase |
| Compatible Techniques | HPLC, LC/MS |
| Brand | Supelco by Merck |
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